GITR Mouse Monoclonal Antibody

Description

EnkiLife offers the GITR Mouse Monoclonal Antibody. This antibody reacts with Human species and is suitable for ELISA,FC application. Alternative Names of Immunogen: TNFRSF18; AITR; CD357; GITR-D. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: ELISA 1:5000-1:20000,FC 1:200-1:400 Background: This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Research Area: Apoptosis,TGF-beta signaling pathway