GENERAL CATALOGUE
Givosiran
HY-132610 · 1 mg
MedChemExpress · Cat: HY-132610
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medchemexpress.com/givosiran.htmlCatalog No: HY-132610
CAS No: 1639325-43-1
Category: Epigenetics
Pack Size: 1 mg
Brand: MedChemExpress
Description
Givosiran ALN-AS1 is a small interfering RNA that targets hepatic aminolevulinate synthase 1 ALAS1 messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic ?-aminolevulinic acid ALA and porphobilinogen PBG levels. Givosiran demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran can be used for the research of acute hepatic porphyria AHP .
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