GENERAL CATALOGUE
GJ19
HY-174830 · 5 mg
MedChemExpress · Cat: HY-174830
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Catalog No: HY-174830
Category: Immunology Inflammation
Pack Size: 5 mg
Brand: MedChemExpress
Description
GJ19 is a PD-L1 inhibitor with an IC50 of 32.06 nM. GJ19 can effectively bind to human/murine PD-L1 protein with KD values of 171 and 290 nM, respectively. GJ19 concentration-dependently promotes HepG2 cell mortality in a co-culture model of HepG2/hPD-L1 and Jurkat T/hPD-1 cells. GJ19 effectively suppresses tumor growth in a B16-F10 melanoma mouse model. GJ19 can be used for the study of tumor immunotherapy.
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