GENERAL CATALOGUE
GK470
HY-120050 · 50 mg
MedChemExpress · Cat: HY-120050
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Catalog No: HY-120050
CAS No: 1621517-53-0
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
GK470 compound 28 is an inhibitor of group IVA cytosolic phospholipase A2 GIVA cPLA2 with an IC50 of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC50 value of 0.6 ?M. GK470 exhibits comparable anti-inflammatory effects to Methotrexate HY-14519 in a preventive collagen-induced arthritis model and significantly reduces plasma PGE2 levels.
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