GENERAL CATALOGUE
GL64
HY-175232 · 5 mg
MedChemExpress · Cat: HY-175232
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Catalog No: HY-175232
CAS No: 488801-10-1
Category: Immunology Inflammation
Pack Size: 5 mg
Brand: MedChemExpress
Description
GL64 is a selective agonist of ADGRD1 EC50 = 3.98 ?M . GL64 has low selectivity for ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4 isoforms. GL64 activates ADGRD1 by mimicking the satchel sequence. GL64 regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. GL64 effectively inhibits osteoclastogenesis and prevents bone loss both in vitro and in vivo. GL64 is useful in the study of osteoclast-related diseases.
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