GENERAL CATALOGUE
?-Glu-PAB(CH2NH2)-Exatecan
HY-173703 · 1 mg
MedChemExpress · Cat: HY-173703
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medchemexpress.com/%CE%B2-glu-pab-ch2nh2-exatecan.htmlCatalog No: HY-173703
CAS No: 3025108-11-3
Category: Cell Cycle DNA Damage
Pack Size: 1 mg
Brand: MedChemExpress
Description
?-Glu-PAB CH2NH2 -Exatecan Compound 9a is a topoisomerase I inhibitor. ?-Glu-PAB CH2NH2 -Exatecan binds to the topoisomerase I-DNA complex to prevent DNA strand reconnection, thereby inducing DNA breakage and cell apoptosis. ?-Glu-PAB CH2NH2 -Exatecan can be specifically cleaved by ?-glucuronidase highly expressed in the tumor microenvironment to release Exatecan for cytotoxic effect. ?-Glu-PAB CH2NH2 -Exatecan is also an intermediate of Mal 3S,3aR,6S,6aR -hexahydrofuro 3, 2-B furan-3,6-diamine-PEG12 -? -Glu-Pab-Exatecan. ?-Glu-PAB CH2NH2 -Exatecan is promising for research of cancers.
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