

HY-173397 · 50 mg
MedChemExpress · Cat: HY-173397
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medchemexpress.com/%CE%B2-glucuronidase-in-3.htmlDescription
?-Glucuronidase-IN-3 Compound 49 is a covalent allosteric ?-glucuronidase inhibitor. ?-Glucuronidase-IN-3 has potent inhibitory activity against Escherichia coli ?-glucuronidase EcGUS IC50: 12.9 nM . ?-Glucuronidase-IN-3 exerts its inhibitory effect by reversibly covalently modifying the cysteine residues Cys28, Cys443, and Cys197 of EcGUS. ?-Glucuronidase-IN-3 can be used in the study of intestinal microbiota-related diseases, especially to alleviate the toxic side effects of Irinotecan HY-16562 and nonsteroidal anti-inflammatory drugs NSAIDs .







