GENERAL CATALOGUE
?-Glucuronide-dPBD-PEG5-NH2
HY-145736 · 50 mg
MedChemExpress · Cat: HY-145736
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Catalog No: HY-145736
CAS No: 2246363-68-6
Category: Antibody-drug Conjugate ADC Related
Pack Size: 50 mg
Brand: MedChemExpress
Description
?-Glucuronide-dPBD-PEG5-NH2 is the ?-glucuronide-linked pyrrolobenzodiazepine dimer, which binds to the prenylated antibody for synthesis of antibody-drug conjugate ADC cIRCR201-dPBD. ?-glucuronide-linkage as a cleavable linker. ?-Glucuronide-dPBD-PEG5-NH2, as a proagent of cIRCR201-dPBD, reduces side effects. ?-Glucuronide-dPBD-PEG5-NH2 can induce apoptosis and arrest cell cycle. ?-Glucuronide-dPBD-PEG5-NH2 has antitumor activity.
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