GENERAL CATALOGUE
GMB-475
HY-125834 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-125834
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medchemexpress.com/gmb-475.htmlCatalog No: HY-125834
CAS No: 2490599-18-1
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
GMB-475 is a potent BCR-ABL1 PROTAC based on Von Hippel-Lindau VHL . GMB-475 targets the nutmeg pocket of ABL1 in an ectopic manner and degrades BCR-ABL1 protein through the ubiquitin proteasome pathway. GMB-475 inhibits the proliferation of human K562 cells and mouse Ba/F3 cells, and is used for the study of chronic myeloid leukemia. Blue: VHL ligand HY-125845 ; Black: Linker; Pink: BCR-ABL1 ligand HY-11007 .