GENERAL CATALOGUE
GNE-064
HY-149026 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-149026
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Manufacturer product page
medchemexpress.com/gne-064.htmlCatalog No: HY-149026
CAS No: 1997321-20-6
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
GNE-064 compound 5 is a selective, orally active and highly soluble inhibitor of SMARCA4, SMARCA2 and PBRM1 bromodomains 5. GNE-064 inhibits SMARCA4 with an IC50 of 0.035 ?M and inhibits SMARCA2 with an EC50 of 0.10 ?M. GNE-064 possess Kds with 0.01, 0.016, 0.018 and 0.049 ?M for SMARCA4, SMARCA2, PBRM1 bromodomains 5 and PBRM1 bromodomains 2, repectively. GNE-064 can be used as a chemical probe for the research of agent synthesis.
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