GENERAL CATALOGUE
GNE-987
HY-129937A · 1 mg
MedChemExpress · Cat: HY-129937A
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medchemexpress.com/gne-987.htmlCatalog No: HY-129937A
CAS No: 2417371-71-0
Category: Epigenetics
Pack Size: 1 mg
Brand: MedChemExpress
Description
GNE-987 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. GNE-987 exhibits picomolar cell BRD4 degradation activity DC50=0.03 nM for EOL-1 AML cell line . GNE-987 binds equipotently to the BD1 and BD2 bromodomains of BRD4 with low nanomolar affinities IC50=4.7 and 4.4 nM, respectively . GNE-987 incorporates a potent BET binder/inhibitor, a VHL-binding fragment, and a ten methylene spacer moiety. GNE-987 can be used in PROTAC-Antibody Conjugate PAC .
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