GENERAL CATALOGUE
GO-203 TFA
HY-P1925A · 1 mg
MedChemExpress · Cat: HY-P1925A
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medchemexpress.com/go-203-tfa.html
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Catalog No: HY-P1925A
CAS No: 1222186-26-6
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR TP53-induced glycolysis and apoptosis regulator protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice.
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