GPI 15427

Description

GPI 15427 is a potent inhibitor of the enzyme poly ADP-ribose polymerase-1 PARP-1 , which plays a harmful role during inflammation. In a rat model of gut injury and inflammation, including splanchnic artery occlusion SAO shock and dinitrobenzene sulfonic acid DNBS -induced colitis, GPI 15427 demonstrated strong anti-inflammatory effects. It reduced inflammatory cell infiltration, histological injury, and delayed clinical signs of inflammation. GPI 15427 also diminished the accumulation of poly ADP-ribose in the ileum and colon of treated rats. These results suggest GPI 15427 could be useful for treating intestinal ischemia and inflammation.