GRB7 (4L2) Rabbit Monoclonal Antibody

Description

EnkiLife offers the GRB7 (4L2) Rabbit Monoclonal Antibody. This antibody reacts with Human species and is suitable for WB,IHC,IF-P application. Alternative Names of Immunogen: B47; Epidermal growth factor receptor GRB 7; GRB7 adapter protein; GRB7;. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1000-1:10000,IHC 1:200-1:500,IF-P 1:200-1:500 Background: Interacts with the cytoplasmic domain of the epidermal growth factor receptor which is then inhibited. The interaction is mediated by the SH2 domain. Also binds to ERBB2. Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity).