Groenlandicine

Description

Groenlandicine, a protoberberine alkaloid, is a cholinesterase inhibitor AChE IC50 = 0.54 ?M , BChE IC50 = 3.32 ?M . Groenlandicine non-competitively inhibits BACE1 IC50 = 19.68 ?M, Ki = 21.2 and inhibits RLAR IC50 = 140.1 ?M , HRAR IC50 = 154.2 ?M , and total ROS generation IC50 = 51.78 ?M in vitro. Groenlandicine suppresses osteosarcoma cell proliferation while promoting apoptosis. Groenlandicine inhibits the tumor growth when combined with Cisplatin HY-17394 . Groenlandicine can be used for the study on osteosarcoma, Alzheimers disease and diabetes mellitus .