GENERAL CATALOGUE
GSK-872
HY-101872 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-101872
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medchemexpress.com/GSK_acute_872.htmlCatalog No: HY-101872
CAS No: 1346546-69-7
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.