GENERAL CATALOGUE
GSK-J4
HY-15648B · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-15648B
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medchemexpress.com/GSK-J4.htmlCatalog No: HY-15648B
CAS No: 1373423-53-0
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 ?M, respectively. GSK-J4 inhibits LPS-induced TNF-? production in human primary macrophages with an IC50 of 9 ?M. GSK J4 is a cell permeable proagent of GSK-J1. GSK-J4 induces endoplasmic reticulum stress-related apoptosis.
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