GENERAL CATALOGUE
GSK_WRN4
HY-163942 · 1 mg
MedChemExpress · Cat: HY-163942
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medchemexpress.com/gsk-wrn4.htmlCatalog No: HY-163942
CAS No: 2923008-66-4
Category: Cell Cycle DNA Damage
Pack Size: 1 mg
Brand: MedChemExpress
Description
GSKWRN4 is an orally active WRN helicase inhibitor pIC50=7.6 . GSKWRN4 induces DNA damage markers p21, p-?H2AX, p-KAP1 . GSKWRN4 selectively inhibits microsatellite-unstable tumor growth in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and regions of DNA damage.
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