GENERAL CATALOGUE
GSK2556286
HY-147017 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-147017
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medchemexpress.com/gsk2556286.htmlCatalog No: HY-147017
CAS No: 1210456-20-4
Category: Anti-infection
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
GSK2556286 GSK286 is an orally active and cholesterol-dependent Mycobacterium tuberculosis inhibitor. GSK2556286 inhibits Mycobacterium tuberculosis inside infected macrophages IC50 = 0.07 ?M in THP-1 cells , in the presence of cholesterol. GSK2556286 acts via Rv1625c, a membrane-bound adenylyl cyclase in Mycobacterium tuberculosis. GSK2556286 is an Rv1625 agonist leading to increased cAMP and reduced cholesterol metabolism. GSK2556286 can be studied in research for antitubercular purposes.
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