GENERAL CATALOGUE
GSK321
HY-18948 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-18948
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Catalog No: HY-18948
CAS No: 1816331-63-1
Category: Metabolic Enzyme Protease
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
GSK321 is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. GSK321 induces decrease in intracellular ?-Hydroxyglutaric acid 2-HG HY-113038B , abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. GSK321can be used for research of acute myeloid leukemia AML and other cancers.
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