GSK3368715 trihydrochloride

Description

GSK3368715 trihydrochloride EPZ019997 is an orally active, reversible, and S-adenosyl-L-methionine SAM uncompetitive type I protein arginine methyltransferases PRMTs inhibitor IC50=3.1 nM PRMT1 , 48 nM PRMT3 , 1148 nM PRMT4 , 5.7 nM PRMT6 , 1.7 nM PRMT8 . GSK3368715 trihydrochloride EPZ019997 produces a shift in arginine methylation states, alters exon usage, and has strong anti-cancer activity.