GENERAL CATALOGUE
GSK3494245
HY-127102 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-127102
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medchemexpress.com/gsk3494245.htmlCatalog No: HY-127102
CAS No: 2080410-41-7
Category: Anti-infection
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
GSK3494245 DDD01305143 is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the ?4 and ?5 subunits IC50=0.16 ?M for WT L. donovani proteasomes . GSK3494245 moderately inhibits chymotrypsin-like activity of human proteasome IC50: purified 26S=13 AAasAasAAmuM; enriched THP-1 extracts IC50=40AAasAasAAmuM . GSK3494245 exhibits attractive biological and biosafety properties.
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