GENERAL CATALOGUE
GSK8814
HY-114204 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-114204
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medchemexpress.com/gsk8814.htmlCatalog No: HY-114204
CAS No: 1997369-78-4
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
GSK8814 is a potent and selective ATAD2 bromodomain chemical probe and inhibitor IC50 = 0.059 ?M , with a binding constant pKd = 8.1 and a pKi = 8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC50s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 can be researched for cancer associated with ATAD2 bromodomain.
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