GSNOR-IN-1

Description

GSNOR-IN-1, a prodrug of GSNOR-IN-2 HY-176275 , is a BBB-penetrable S-nitrosoglutathione reductase GSNOR inhibitor. GSNOR-IN-1 has significant protective activity against OGD/R-induced injury. GSNOR-IN-1 regulates calcium signaling and synaptic function via Clstn1 S-nitrosation and inhibits neuronal apoptosis. GSNOR-IN-1 significantly reduces infarct volume while improving neurological deficits in ischemic stroke rat models. GSNOR-IN-1 has neuroprotective activity, promising for ischemic stroke research.