GENERAL CATALOGUE
GT-653
HY-158432 · 1 mg
MedChemExpress · Cat: HY-158432
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Manufacturer product page
medchemexpress.com/gt-653.htmlCatalog No: HY-158432
Category: Epigenetics
Pack Size: 1 mg
Brand: MedChemExpress
Description
GT-653 is a PROTAC degrader for lysine-specific demethylase 5B KDM5B . GT-653 degrades 68.35 % KDM5B at 10 ?M in a ubiquitin proteasome-dependent manner, upregulates H3K4me3 levels, and activates the type-I interferon signaling pathway in prostate cancer cells 22RV1. Pink: KDM5B ligand HY-158433 ; Black: Linker HY-W004896 ; Blue: E3 ligase ligand HY-103596
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