GENERAL CATALOGUE
GW405833 hydrochloride
HY-110036A · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-110036A
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medchemexpress.com/gw405833-hydrochloride.htmlCatalog No: HY-110036A
CAS No: 1202865-22-2
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
GW405833 L768242 hydrochloride is a potent, selective cannabinoid receptor 2 CB2 agonist. GW405833 has EC50 and Ki values of 0.65 nM and 3.92 nM for CB2, and EC50 and Ki values of 16.1 ?M and 4772 nM for CB1. GW405833 hydrochloride also exhibits non-competitive CB1 antagonist, exerting its analgesic effect through a CB1 receptor rather than CB2 dependent mechanism. GW405833 hydrochloride can significantly inhibit the production of cAMP stimulated by Forskolin HY-15371 . GW405833 hydrochloride inhibits glycolysis by down-regulating HIF-1?, thereby alleviating acute liver failure ALF .
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