GENERAL CATALOGUE
GW7845
HY-121746 · 50 mg
MedChemExpress · Cat: HY-121746
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medchemexpress.com/gw7845.htmlCatalog No: HY-121746
CAS No: 196809-22-0
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPAR? agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels VDCC and relaxing pressurized arteries with IC50 of 3 ?M by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells.
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