GENERAL CATALOGUE
H122
HY-172113 · 1 mg
MedChemExpress · Cat: HY-172113
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medchemexpress.com/h122.htmlCatalog No: HY-172113
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
H122 is a PROTAC degrader for TEAD that degrades TEAD1 with a DC50 of 3 nM, and exhibits good affinity to TEAD2, TEAD3, and TEAD4 with Ki of 2.0, 3.6 and 1.6 nM. H122 downregulates the expression of Myc. H122 inhibits the cell growth of MSTO-211H and NCI-H226 with IC50 of 21.3 nM and 0.6 nM, and exhibits antitumor efficacy in mouse models. Pink: ligand for target protein HY-151525 ; Black: linker HY-W573128 ; Blue: ligand for E3 ligase Cereblon HY-W087383
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