

HY-N1584 · 5 mg
MedChemExpress · Cat: HY-N1584
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medchemexpress.com/Halofuginone.html
Description
Halofuginone RU-19110 , a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis OA by inhibition of TGF-? activity. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.







