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Halofuginone hydrobromide
GENERAL CATALOGUE

Halofuginone hydrobromide

HY-N1584A · 10 mM * 1 mL in DMSO

MedChemExpress · Cat: HY-N1584A

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Catalog No: HY-N1584A
CAS No: 64924-67-0
Category: Anti-infection
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress

Description

Halofuginone RU-19110 hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis OA by inhibition of TGF-? activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.

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