GENERAL CATALOGUE
Halofuginone hydrochloride
HY-N1584B · 1 mg
MedChemExpress · Cat: HY-N1584B
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Catalog No: HY-N1584B
CAS No: 1217623-74-9
Category: Anti-infection
Pack Size: 1 mg
Brand: MedChemExpress
Description
Halofuginone RU-19110 hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis OA by inhibition of TGF-? activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
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