Halofuginone hydrochloride (Standard)

Description

Halofuginone hydrochloride Standard is the analytical standard of Halofuginone hydrochloride . This product is intended for research and analytical applications. Halofuginone RU-19110 hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis OA by inhibition of TGF-? activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects 4 .