GENERAL CATALOGUE
Halofuginone lactate
HY-N1584C · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-N1584C
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Catalog No: HY-N1584C
CAS No: 82186-71-8
Category: Anti-infection
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Halofuginone lactate, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone lactate is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis OA by inhibition of TGF-? activity. Halofuginone lactate is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone lactate has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects.
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