HBL-2 Cells

Description

The HBL-2 cell line is derived from an AIDS-SNCCL patient. After immunophenotypic and molecular genetic analysis, derivation of HBL-2 from the original tumor clones was established. The HBL-2 cell line presents with surface immunoglobulin and B-cell restricted markers as well as a phenotype consistent with SNCCL; the cell line also displays clonal immunoglobulin gene rearrangement. The HBL-2 cell line is considered useful as a biological model to study AIDS-NHL lymphomagenesis and the impacts of biological, immunological, and viral factors involved.