HBO1 Rabbit Polyclonal Antibody

Description

EnkiLife offers the HBO1 Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,ICC/IF,ELISA application. Alternative Names of Immunogen: KAT7; HBO1; HBOa; MYST2; Histone acetyltransferase KAT7; Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ; YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,ICC/IF 1:200-1:1000,ELISA 1:10000-1:20000 Background: catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone. domain:The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L. domain:The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction. function:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. PTM:Phosphorylated upon DNA damage, probably by ATM or ATR. similarity:Belongs to the MYST (SAS/MOZ) family. similarity:Contains 1 C2HC-type zinc finger. subunit:Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2/HBO1, EAF6, and one of PHF15, PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. tissue specificity:Ubiquitously expressed, with highest levels in testis. Research Area:Protein_Acetylation