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hCA/VEGFR-2-IN-2
GENERAL CATALOGUE

hCA/VEGFR-2-IN-2

HY-155758 · 50 mg

MedChemExpress · Cat: HY-155758

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Catalog No: HY-155758
CAS No: 2971782-66-6
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress

Description

hCA/VEGFR-2-IN-2 compound 8g is an indolinonylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-2 inhibits VEGFR-2 IC50=204 nM and has high binding activity to hCAs, with Kis of 3.6 nM hCA IX , 16.1 nM hCA II , 16.7 nM hCA XII , and 75.3 nM hCA I , respectively. hCA/VEGFR-2-IN-2 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells.

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