hCA/VEGFR-2-IN-4

Description

hCA/VEGFR-2-IN-4 compound 15b is an indolinylbenzenesulfonamide and a potential dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. hCA/VEGFR-2-IN-4 inhibits VEGFR-2 IC50=0.811 ?M and has high binding activity to hCAs, with Ki of 3.8 nM hCA XII , 6.2 nM hCA IX , 19.8 nM hCA II , and 35.5 nM hCA I , respectively. hCA/VEGFR-2-IN-4 has antiproliferative activity on VEGFR-2-overexpressing breast cancer cells.