HDAC-IN-27 dihydrochloride

Description

HDAC-IN-27 dihydrochloride Compound 11h is a potent, orally active class I HDAC-selective inhibitor with IC50 values ranging from 0.43 to 3.01 nM against HDAC1-3. HDAC-IN-27 dihydrochloride exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 dihydrochloride demonstrates significant anti-proliferative activity against acute myeloid leukemia AML cell lines by inducing apoptosis and histone acetylation AcHH3 and AcHH4 . HDAC-IN-27 dihydrochloride can be used for research in acute myeloid leukemia AML .