HDAC-IN-34

Description

HDAC-IN-34 compound 27 is a potent HDAC inhibitor, with IC50 values of 0.022 and 0.45 ?M for HDAC1 and HDAC6, respectively. HDAC-IN-34 can bind to DNA and cause DNA damage. HDAC-IN-34 causes cells apoptosis through p53 signaling pathway. HDAC-IN-34 exhibits significant anti-proliferation effect against HCT-116 cells, with an IC50 of 1.41 ?M.