GENERAL CATALOGUE
HDAC-IN-47
HY-151443 · 50 mg
MedChemExpress · Cat: HY-151443
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Manufacturer product page
medchemexpress.com/hdac-in-47.htmlCatalog No: HY-151443
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
HDAC-IN-47 is an orally active inhibitor of histone deacetylase HDAC , with IC50s of 19.75 nM HDAC1 , 5.63 nM HDAC2 , 40.27 nM HDAC3 , 57.8 nM HDAC2 , 302.73 nM HDAC8 , respectively. HDAC-IN-47 inhibits autophagy and induces apoptosis via the Bax/Bcl-2 and caspase-3 pathways. HDAC-IN-47 arrests cell cycle at G2/M phase, and shows anti-tumor efficacy in vivo.
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