GENERAL CATALOGUE
HDAC-IN-53
HY-149208 · 1 mg
MedChemExpress · Cat: HY-149208
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medchemexpress.com/hdac-in-53.htmlCatalog No: HY-149208
CAS No: 2921948-27-6
Category: Apoptosis
Pack Size: 1 mg
Brand: MedChemExpress
Description
HDAC-IN-53 is an orally active, and selective HDAC1-3 inhibitor with IC50 values of 47 nM, 125 nM, and 450 nM, respectively. HDAC-IN-53 does not inhibit class II HDACs HDAC4, 5, 6, 7, 9; IC50 10 ?M. HDAC-IN-53 induces caspase-dependent apoptosis. HDAC-IN-53 significantly inhibits the growth of human tumor xenografts in nude mice and murine tumor growth in immune-competent mice bearing MC38 colon cancer.
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