HDAC-IN-73

Description

HDAC-IN-73 compound P-503 is a histone deacetylase HDAC inhibitor. HDAC-IN-73 shows IC50s values of 0.17, 0.49 AAasAasAAmuM for HDAC1 and HDAC6, respectively. Notably, HDAC-IN-73s inhibitory potency against HDAC6 is heightened, exhibiting a 9-fold greater efficacy than PsA HY-N2150 IC50=3.9 ?M . HDAC-IN-73 shows potent antiproliferative activity, induces apoptosis, and causes cell cycle arrest at G2 / M phase. HDAC-IN-73 has the potential to be used for the research of cancer such as colon cancer .