HDAC/PSMD14-IN-1

Description

HDAC/PSMD14-IN-1 Compound 8B is a thiolutin derivative. HDAC/PSMD14-IN-1 is a orally active dual-target inhibitor of PSMD14/HDAC1 IC50 238.7 nM/141.2 nM, respectively . HDAC/PSMD14-IN-1 has good cytotoxicity against ESCC cell lines IC50: 30-250 nM and effectively reverses epithelial-mesenchymal transition EMT . HDAC/PSMD14-IN-1 can induce apoptosis. HDAC/PSMD14-IN-1 has anti-tumor activity in a KYSE30 cell mouse xenograft model. HDAC/PSMD14-IN-1 can be used in anti-esophageal cancer research.