HDAC6-IN-45

Description

HDAC6-IN-45 Compound 15 is a selective inhibitor for HDAC6 with IC50 of 15.2 nM. HDAC6-IN-45 exhibits neurotrophic through the upregulation of GAP43 and Beta-3 tubulin markers. HDAC6-IN-45 activates the Nrf2 signaling pathway, reduces H2O2-induced ROS production, inhibits apoptosis in PC12, and exhibits neuroprotective efficacy in SCOP-induced zebrafish Alzheimers Disease models. HDAC6-IN-45 exhibits antioxidant activity and good blood-brain barrier BBB permeability.