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Hdm2 E3 ligase inhibitor 1
GENERAL CATALOGUE

Hdm2 E3 ligase inhibitor 1

HY-131667 · 50 mg

MedChemExpress · Cat: HY-131667

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Catalog No: HY-131667
CAS No: 414905-09-2
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress

Description

Hdm2 E3 ligase inhibitor 1 Compound 1 is a reversible inhibitor for Hdm2 an E3 ubiquitin ligase -mediated ubiquitination of the p53 protein with an IC50 of 12.7 ?M. Hdm2 E3 ligase inhibitor 1 binds Hdm2, blocks Hdm2-catalyzed ubiquitin transfer from preligated Ub-Ubc4 to p53, inhibits p53 ubiquitination, stabilizes p53 protein in tumor cell and exhibits antitumor efficacy.

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