Hellebrigenin

Description

Hellebrigenin is an inhibitor that selectively targets the MAPK signaling pathway ERK, p38, JNK and XIAP, and can inhibit Akt expression and phosphorylation. Hellebrigenin can activate endogenous apoptosis pathways such as mitochondrial membrane potential disruption, Caspase family activation, PARP cleavage , downregulate anti-apoptotic proteins Bcl-2, Bcl-xL and upregulate pro-apoptotic proteins Bax, Bak . Hellebrigenin can also induce DNA double-strand breaks to activate the ATM pathway. Hellebrigenin can inhibit tumor cell proliferation and clone formation, and is mainly used in the study of oral squamous cell carcinoma, liver cancer and other cancers.