Hibifolin

Description

Hibifolin is a flavonol glycoside that can be isolated from Helicteres isora. Hibifolin is an inhibitor of adenosine deaminase ADA Ki = 49.92 ?M . Hibifolin protects neurons against ?-amyloid-induced neurotoxicity. Hibifolin possesses a potent protective activity against cell death induced by aggregated A?. Hibifolin can abolish A?-induced caspase-3 and caspase-7 activation. Hibifolin induces Akt phosphorylation in cortical neurons. Hibifolin is also a natural sortase A SrtA inhibitor IC50 = 31.2 ?M through direct binding to SrtA protein. Hibifolin attenuates the pathogenic behavior of Staphylococcus aureus including adhesion, invasion, and biofilm formation. Hibifolin improves the survival of pneumonia induced by Staphylococcus aureus in mouse model and alleviates pathological damage. Hibifolin shows a synergistic antibacterial effect with Cefotaxime HY-A0088A .