Higenamine

Description

Higenamine Norcoclaurine , a ?2-AR agonist with antioxidant capability, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine is also a ?1-adrenergic receptor antagonist with hypotensive effect. is a selective LSD1 inhibitor IC50=1.47 ?M that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine protects myocyte Apoptosis and ischemia/reperfusion I/R injury through selective activation of beta2-adrenergic receptor ?2-AR . Higenamine also reduces I/R-induced myocardial infarction in mice. Higenamine can attenuate IL-1?-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine can be used to study cancer, inflammation, cardiorenal syndrome and other diseases.