HIRA Rabbit Monoclonal Antibody

Description

EnkiLife offers the HIRA Rabbit Monoclonal Antibody. This antibody reacts with Human species and is suitable for WB,ICC/IF,FC,IP application. Alternative Names of Immunogen: TUP1; DGCR1; TUPLE1. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1000-1:5000,ICC/IF 1:50-1:200,FC 1:100-1:1000,IP 1:10-1:100 Background: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]