HIV-1-IN-83

Description

HIV-1-IN-83 Compound 18E is a HIV-1 non-nucleoside reverse transcriptase inhibitor with an IC50 of 0.45 ?M for wild-type HIV-1 non-nucleoside reverse transcriptase. HIV-1-IN-83 has potent antiviral activity against both HIV-1 wild-type and mutant strains and improves antidrug resistance for Y188L and RES056 mutant strains. HIV-1-IN-83 has no significant toxicity up to 11.088 ?M.